To support the development of novel therapies in Neuroscience and Neuro-oncology we need access to human tissue such as adult and fetal human brain tissue, blood and Cerebrospinal Fluid (CSF).
Supplementary to our Human Tissue Lab, we also work across two sites in Cardiff and Swansea to support Neurological Biobanking and tissue phenotyping. Learn more about Biobanking
We have set up a unique human adult tissue facility to perform 2D and 3D culturing of primary brain tissue for disease modelling
The tissue used for research is obtained by collecting excess tissue removed from brain surgery. Surgeries include:
We use cultures of human brain to study how the brain works and what goes wrong in disease. We look at:
Translation and validation of mechanisms and potential therapies from animal studies in:
Learn more about
BioBanking at BRAIN
We are using a unique method for culturing human brain tissue to study disease mechanisms and test new therapies. These cultures are 3-dimensional and capture the heterogeneity of human brain cells. This allows us to research different neurological diseases (e.g. epilepsy, traumatic brain injury and cancer) and model the individual response to potential therapies.
Using Cerebrospinal Fluid (CSF) samples from patients with suspected infection we are examining the use of immune markers to accurately diagnose infection much earlier than with standard microbiology cultures and so treat patients earlier.
Collaboration with Prof M Eberl, Dr S Cuff, Dr J Merola & Prof W Gray.
Our human fetal (hF) tissue collections are unique in the UK in providing high quality hF brain tissues for research and clinical application. We have used this tissue for critical preclinical cell replacement therapy (CRT) research, understanding neurodegenerative and developmental mechanisms and underpinning CRT clinical trials.