About us

Funded by Welsh Government via the Health and Care Research Wales infrastructure, the Brain Repair and Intracranial Neurotherapeutics (BRAIN) is a research unit developing novel therapeutics and treatment delivery systems for neurological conditions.

BRAIN operates under the directorship of Professor William Gray with 31 principle investigators and collaborators, with a total grant income of over £34 million since its inception in 2015.

Our Mission

It is our vision that the Brain Repair and Intracranial Neurotherapeutics (BRAIN) unit will be a Welsh and UK national centre of excellence, and on a path towards  international leadership for:

1. Delivering novel cell/gene/small  molecules and other pioneering complex therapies to human brain.
2. Supporting translational research underpinning disease modification and brain repair in patients with neurological conditions.

Our aims for the next three years are:

1. To develop new and refine existing systems for therapeutics delivery into the human brain
2. Develop appropriate infrastructure for:
   1. Developing adult and fetal brain tissue resources, supporting translational research and therapy validation across neurological diseases
   2. Bio-banking and bio-resource management using linked and deeply phenotyped clinical data
3. Consolidate and extend appropriate clinical trials and expertise, including refinement of appropriate methodologies for evaluating novel complex interventions
4. Embed into all BRAIN work, cross-cutting excellence in the relation to:
   1. Public and Patient Involvement & Engagement
   2. Industry and NHS Engagement and Collaboration