Our Research

The Advanced Neurotherapies Centre (ANTC), previously known as the BRAIN Unit, represents a significant and unique opportunity for Wales to lead on the national and international stage, addressing the challenges of ATMP delivery to brain.

Our research covers three central themes, spanning the breadth of the translational pipeline, working to progress early advanced neurotherapy development biology of neurological disease and delivering cutting-edge therapies directly to the brain in early phase clinical trials.

Delivering ATMPs to the human brain in early phase clinical trials

Supporting infrastructure to:

• Consolidate, further expand and make sustainable our ability to safely deliver our first-in-human clinical trial portfolio for neurological ATMPs.

Supporting translational research for:

• Delivery science – to address the key challenges of ATMP delivery to the brain

Supporting ATMP development for neurological disease

Supporting infrastructure for:

• Supplying adult and foetal living human brain tissue
• Supporting research in Wales underpinning target identification and early ATMP development for neurological diseases and their underlying molecular and cellular neurobiology.

Using people’s lived experience to improve how our trials are designed

Strong and sustainable clinical trial activity is central to our strategy for building a truly translational research programme.