{"id":3794,"date":"2021-06-01T09:43:29","date_gmt":"2021-06-01T08:43:29","guid":{"rendered":"https:\/\/brain.wales\/2021\/06\/cwrdd-ar-ymchwilydd-dr-malik-zaben\/"},"modified":"2026-03-03T14:48:23","modified_gmt":"2026-03-03T14:48:23","slug":"cwrdd-ar-ymchwilydd-dr-malik-zaben","status":"publish","type":"post","link":"https:\/\/brain.wales\/cy\/2021\/06\/cwrdd-ar-ymchwilydd-dr-malik-zaben\/","title":{"rendered":"Cwrdd \u00e2’r ymchwilydd: Dr Malik Zaben"},"content":{"rendered":"

Mae Dr Zaben yn ddarlithydd mewn niwrolawdriniaeth gyda diddordeb arbennig mewn deall niwrogenesis a niwroplastigedd ar \u00f4l anaf trawmatig i’r ymennydd (TBI). <\/span>Mae ei ymchwil yn archwilio dulliau therapiwtig posibl sy’n targedu llwybrau niwro-llidiol i gyfyngu ar ddifrod i’r ymennydd ar \u00f4l anaf, a gwella atgyweirio.<\/span><\/p>\n

\"graffig<\/p>\n

Mae eleni wedi bod yn flwyddyn lwyddiannus arall i’n t\u00eem ymchwil Anafiadau Trawmatig i’r Ymennydd ym Mhrifysgol Caerdydd, er gwaethaf yr heriau y mae pandemig COVID-19 wedi’u hachosi.<\/span><\/p>\n

Rydym wedi gallu mynd i’r afael \u00e2 rhai agweddau newydd ar ein maes ymchwil sy’n cwmpasu’r sbectrwm eang o wyddoniaeth sylfaenol ac ymchwil glinigol.<\/span><\/p>\n

Yr ymchwil<\/span><\/h2>\n

Roedd pandemig COVID-19 yn golygu bod yn rhaid i ni adael y labordy ganol mis Mawrth 2020 ac nid oeddem yn gallu dychwelyd tan ganol mis Gorffennaf.<\/span><\/p>\n

Er gwaethaf yr aflonyddwch mawr hwn, rydym bellach yn gallu parhau \u00e2’n hymchwil yn fewnol. Gan adeiladu ar ein canfyddiadau blaenorol, rydym wedi cynhyrchu data newydd a pherthnasol ar y llwybrau llidiol a sbardunir gan drawiadau ac Anaf Trawmatig i’r Ymennydd (TBI), sydd \u00e2 chysylltiad cryf \u00e2 diffygion niwrowybyddol hirdymor mewn cleifion o’r ddau gategori.<\/span><\/p>\n

Ein targed allweddol o ddiddordeb yw HMGB1, protein sy’n cael ei ryddhau gan gelloedd imiwnedd yn sylweddol ar \u00f4l epilepsi a TBI ac sy’n cael ei gydnabod fwyfwy fel ‘switsh meistr niwro-llid yn y cyfnod ac\u00edwt ar \u00f4l anaf’.<\/span><\/p>\n

Mae lefelau uwch o HMGB1 yng ngwaed cleifion \u00e2 TBI yn gysylltiedig \u00e2 chanlyniad gwaeth mewn cleifion ag epilepsi yn ogystal \u00e2 TBI. Gallai blocio’r protein hwn mewn modd amser-benodol gynnig yr ateb i leddfu’r amgylchedd niwro-wenwynig a gr\u00ebwyd ar \u00f4l anaf a gwella atgyweirio’r ymennydd.<\/p>\n

Er i ni weld rhyddhau sylweddol o HMGB1 ar \u00f4l anaf yn flaenorol, rydym bellach wedi darganfod bod gan HMGB1 effaith niweidiol ar allu celloedd bonyn niwral i gynhyrchu niwronau newydd neu atgyweirio ffibrau celloedd nerf ar \u00f4l anaf.<\/p>\n

Eleni rydym hefyd wedi nodi’r derbynyddion a’r llwybrau sy’n gysylltiedig \u00e2’r effaith uchod ac, yn bwysicach fyth, wedi llwyddo i wrthdroi effeithiau HMGB1 gan ddefnyddio rhai strategaethau cyffuriau newydd.<\/span><\/p>\n

Mae’r canfyddiadau hyn yn paratoi’r ffordd ar gyfer nodi cyffuriau posibl y gellir eu defnyddio i wella atgyweirio celloedd nerf ar \u00f4l anaf.<\/span><\/p>\n

Rydym bellach wedi cyhoeddi rhai o’n canfyddiadau allweddol mewn dau bapur a adolygwyd gan gymheiriaid yn y<\/span> Journal of Brain Science<\/a> a’r<\/span> Journal of Scientific Reports<\/a> .<\/span><\/p>\n

Rydym wedi cyflwyno ein gwaith ar lwybrau sy’n cynnwys HMGB1 a cytocinau llidiol eraill sy’n gysylltiedig ag epilepsi i’w gyhoeddi yn y Journal of Neuroinflammation (dan adolygiad).<\/span><\/p>\n

Beth nesaf?<\/span><\/h2>\n

Wrth symud ymlaen, byddwn yn dilysu ein canfyddiadau mewn meinwe ymennydd dynol. Gyda chydsyniad cleifion sy’n cael niwrolawdriniaeth, byddwn yn cael samplau bach o feinwe ymennydd arferol a fyddai fel arall wedi cael eu taflu fel rhan arferol o’r llawdriniaeth.<\/span><\/p>\n

Yna gallwn dyfu’r celloedd hyn mewn system ddiwylliant in vitro 3D arbenigol sy’n dynwared eu hamgylchedd rhiant naturiol yn agos in vivo. Gyda modelau anafiadau colli pwysau a gyfrifwyd yn ddoeth; rydym yn astudio effeithiau rhwystro HMGB1 ar wella atgyweirio’r ymennydd ar \u00f4l anaf.<\/span><\/p>\n

Gyda thystiolaeth o feinwe cnofilod a meinwe ddynol, rydym yn gobeithio egluro r\u00f4l niweidiol bosibl HMGB1 mewn TBI a darparu targedau therapiwtig addawol ar gyfer gwella canlyniadau mewn cleifion TBI.<\/span><\/p>\n

Rydym yn parhau i wneud cynnydd cyffrous ac rydym yn hynod ddiolchgar am gefnogaeth barhaus ein harianwyr.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Mae Dr Zaben yn ddarlithydd mewn niwrolawdriniaeth gyda diddordeb arbennig mewn deall niwrogenesis a niwroplastigedd ar \u00f4l anaf trawmatig i’r ymennydd (TBI). Mae ei ymchwil yn archwilio dulliau therapiwtig posibl sy’n targedu llwybrau niwro-llidiol i gyfyngu ar ddifrod i’r ymennydd ar \u00f4l anaf, a gwella atgyweirio. Mae eleni wedi bod yn flwyddyn lwyddiannus arall i’n […]<\/p>\n","protected":false},"author":9,"featured_media":3517,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[18],"tags":[17],"class_list":["post-3794","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-heb-ei-gategoreiddio","tag-prydain-fawr"],"acf":[],"yoast_head":"\nCwrdd \u00e2'r ymchwilydd: Dr Malik Zaben - Ymennydd Cymru<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/brain.wales\/cy\/2021\/06\/cwrdd-ar-ymchwilydd-dr-malik-zaben\/\" \/>\n<meta property=\"og:locale\" content=\"cy_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cwrdd \u00e2'r ymchwilydd: Dr Malik Zaben - Ymennydd Cymru\" \/>\n<meta property=\"og:description\" content=\"Mae Dr Zaben yn ddarlithydd mewn niwrolawdriniaeth gyda diddordeb arbennig mewn deall niwrogenesis a niwroplastigedd ar \u00f4l anaf trawmatig i’r ymennydd (TBI). Mae ei ymchwil yn archwilio dulliau therapiwtig posibl sy’n targedu llwybrau niwro-llidiol i gyfyngu ar ddifrod i’r ymennydd ar \u00f4l anaf, a gwella atgyweirio. 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Mae ei ymchwil yn archwilio dulliau therapiwtig posibl sy’n targedu llwybrau niwro-llidiol i gyfyngu ar ddifrod i’r ymennydd ar \u00f4l anaf, a gwella atgyweirio. 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