{"id":3720,"date":"2025-05-15T09:05:34","date_gmt":"2025-05-15T08:05:34","guid":{"rendered":"https:\/\/brain.wales\/2025\/05\/treial-newydd-ar-gyfer-therapi-genynnau-ar-gyfer-dementia-frontotemporal\/"},"modified":"2026-06-15T13:41:15","modified_gmt":"2026-06-15T12:41:15","slug":"treial-newydd-ar-gyfer-therapi-genynnau-ar-gyfer-dementia-frontotemporal","status":"publish","type":"post","link":"https:\/\/brain.wales\/cy\/2025\/05\/treial-newydd-ar-gyfer-therapi-genynnau-ar-gyfer-dementia-frontotemporal\/","title":{"rendered":"Treial newydd ar gyfer therapi genynnau ar gyfer dementia frontotemporal"},"content":{"rendered":"
\n

Bydd treial clinigol<\/span> ASPIRE-FTD<\/span> yn ymchwilio i’r defnydd o therapi genynnau mewn pobl \u00e2 dementia frontotemporal<\/span> .<\/span><\/h3>\n

Bydd treial clinigol newydd, a gynhelir yng Nghaerdydd, yn ymchwilio i’r defnydd o therapi genynnau untro i atal datblygiad y clefyd mewn cleifion \u00e2 dementia frontotemporal.<\/p>\n

Mae treial clinigol Cam 1\/2 ASPIRE-FTD<\/a> yn recriwtio cleifion yn y DU i ymchwilio i ddefnyddio AVB-101, therapi genynnau, mewn pobl \u00e2 dementia frontotemporal gyda mwtaniadau genynnau progranulin (FTD-GRN).<\/p>\n

Bydd y treial, a gynhelir gan AviadoBio<\/a> , yn recriwtio cleifion o bob cwr o Ewrop. Y Ganolfan Niwrotherap\u00efau Uwch ym Mhrifysgol Caerdydd a Bwrdd Iechyd Prifysgol Caerdydd a’r Fro fydd safle llawfeddygol y DU ar gyfer y treial, gan mai’r ganolfan yw’r unig le yn y DU a all gyflenwi cyffuriau’n syth i’r ymennydd dynol mewn sganiwr MRI ar gyfer triniaeth fanwl gywir a delweddu amser real.<\/p>\n<\/div>\n

Mae’r therapi genynnau newydd hwn, AVB-101, yn therapi untro sydd \u00e2’r potensial i atal dilyniant dementia frontotemporal. Er mwyn deall ei effeithiau ar yr ymennydd yn llawn, mae angen i ni oresgyn rhai o’r rhwystrau a all atal cyffuriau rhag cyrraedd yr ymennydd ac mae angen mesuriad manwl gywir arnom hefyd o sut mae’n gweithio. Yn y Ganolfan Niwrotherap\u00efau Uwch, rydym yn gallu cyflwyno cyffuriau’n uniongyrchol i’r ymennydd, gan dargedu rhanbarthau penodol. Nid yn unig hyn, ond rydym yn gallu gwneud hynny mewn sganiwr MRI, i gael delweddu amser real o’r broses a’i heffaith.<\/p><\/blockquote>\n

Yr Athro William Gray, Athro Niwrolawdriniaeth<\/figcaption><\/figure>\n

 <\/p>\n

\n

Caiff AVB-101 ei gyflwyno fel triniaeth untro yn unig gan ddefnyddio gweithdrefn niwrolawfeddygol stereotactig lleiaf ymledol yn uniongyrchol i’r thalamws \u2013 ardal allweddol yn yr ymennydd yr effeithir arni mewn dementia blaen-amserol.<\/p>\n

Dywedodd David Cooper, Prif Swyddog Meddygol AviadoBio: \u201cMae lansio ASPIRE-FTD a thrin ein cleifion cyntaf ag AVB-101 wedi bod yn gerrig milltir arwyddocaol ym maes ymchwil FTD-GRN a datblygu therapi genynnau. Adeiladwyd AviadoBio ar ymchwil arloesol o Goleg y Brenin Llundain a Sefydliad Ymchwil Dementia’r DU. Mae agor ein safleoedd treialon clinigol yn y DU yn adlewyrchu’r dreftadaeth ymchwil gref hon, ac rydym yn falch o ddod \u00e2’r treial clinigol hwn i’r DU i’w wneud yn fwy hygyrch i bobl sy’n byw gyda chlefyd blaen-amserol teuluol yn y rhanbarth.\u201d<\/p>\n<\/div>\n

Rydym wrth ein bodd yn gallu cyflwyno’r treial ASPIRE-FTD yn llawfeddygol yng Nghaerdydd, gan gynnig gobaith i gleifion sy’n byw gyda dementia frontotemporal yn y DU. Y Ganolfan Niwrotherapi Uwch yw’r unig ganolfan yn y DU ac un o ddwy ganolfan yn Ewrop sy’n gallu ymgymryd \u00e2’r math hwn o waith. Mae’r treial hwn yn cynrychioli cam mawr ymlaen yn y chwilio am driniaeth ar gyfer dementia frontotemporal, gan ddod \u00e2 therapi newydd i realiti i gleifion o bosibl.<\/p><\/blockquote>\n

Yr Athro William Gray, Athro Niwrolawdriniaeth<\/figcaption><\/figure>\n

 <\/p>\n

\n

Dywedodd Suzanne Rankin, Prif Swyddog Gweithredol Bwrdd Iechyd Prifysgol Caerdydd a\u2019r Fro, ac Uwch Swyddog Cyfrifol ar gyfer Rhaglen Therap\u00efau Uwch Cymru: \u201cMae\u2019n wych gweld y therap\u00efau uwch hyn yn cael effaith gadarnhaol ar gleifion ledled Cymru. Rwy’n falch bod Bwrdd Iechyd Prifysgol Caerdydd a’r Fro yn parhau i gyfrannu at yr ymchwil gyffrous hon. Mae’n wych gallu cefnogi gwaith mor arloesol, ac rwy’n ddiolchgar i’n hymchwilwyr a’r t\u00eem ehangach a oedd yn rhan o hyn am eu gwaith caled a’u hymroddiad.”<\/p>\n

Uned BRAIN oedd y Ganolfan Niwrotherap\u00efau Uwch gynt, a gynhelir gan Brifysgol Caerdydd, ac a ariennir gan Ymchwil Iechyd a Gofal Cymru.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Bydd treial clinigol ASPIRE-FTD yn ymchwilio i’r defnydd o therapi genynnau mewn pobl \u00e2 dementia frontotemporal . Bydd treial clinigol newydd, a gynhelir yng Nghaerdydd, yn ymchwilio i’r defnydd o therapi genynnau untro i atal datblygiad y clefyd mewn cleifion \u00e2 dementia frontotemporal. Mae treial clinigol Cam 1\/2 ASPIRE-FTD yn recriwtio cleifion yn y DU […]<\/p>\n","protected":false},"author":9,"featured_media":3610,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-3720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newyddion"],"acf":[],"yoast_head":"\nTreial newydd ar gyfer therapi genynnau ar gyfer dementia frontotemporal - Ymennydd Cymru<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/brain.wales\/cy\/2025\/05\/treial-newydd-ar-gyfer-therapi-genynnau-ar-gyfer-dementia-frontotemporal\/\" \/>\n<meta property=\"og:locale\" content=\"cy_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treial newydd ar gyfer therapi genynnau ar gyfer dementia frontotemporal - Ymennydd Cymru\" \/>\n<meta property=\"og:description\" content=\"Bydd treial clinigol ASPIRE-FTD yn ymchwilio i’r defnydd o therapi genynnau mewn pobl \u00e2 dementia frontotemporal . Bydd treial clinigol newydd, a gynhelir yng Nghaerdydd, yn ymchwilio i’r defnydd o therapi genynnau untro i atal datblygiad y clefyd mewn cleifion \u00e2 dementia frontotemporal. 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